Medicine Melancholy

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Medicine Melancholy
me̞disɯ̃ᵝm me̞ɾ̠ã̠ŋko̞ɾiː (♫)
Medicin Melancory
Medicine Melancholy
Medicine Melancholy in Phantasmagoria of Flower View
Little Sweet Poison
More Character Titles

Doll gone youkai


Manipulation of poison




Hill of the Nameless

Music Themes
Official Games
Print Works
"It's not good spreading the smell of poison so much.
It'll make others want to run."
"Poison? Oh, poison. It's my life. That won't change."
Yuuka Kazami and Medicine Melancholy (Phantasmagoria of Flower View Episode 7)

Medicine Melancholy (メディスン・メランコリー Medisun Merankorī) is a young doll youkai that lives on the Hill of the Nameless surrounded by poisonous lily-of-the-valley flowers.

General Information

Medicine first appeared in Phantasmagoria of Flower View as a possible opponent. She was then later shown as a target on Stage 4 of Shoot the Bullet and in the background of Hopeless Masquerade. She is a doll who became youkai after being left in the lily-of-the-valley field on the Hill of the Nameless.


Due to her becoming a youkai only recently and never leaving the Hill of the Nameless, Medicine is very immature and her experience and knowledge are overwhelmingly shallow. Medicine harbors an extreme hatred for humanity, and will actively try to poison anyone near her presence. This combined with her dreadful ability makes Medicine a very frightening youkai who should be avoided at all costs. After being judged by Eiki, Medicine starts to learn how to empathize. Between the events of Phantasmagoria of Flower View and Silent Sinner in Blue, Medicine has learned to be more sociable.


Manipulating poison

Medicine is able to manipulate poison, where she can use the poison on everything; food, attacking and even herself could be covered with poison. It seems to be not merely the poison of lily-of-the-valley, but of all kinds. For example, the poison of wasps, snakes, spiders, alcohol, nicotine, etc. It has the effect such that even touching her will cause inflammation; there's currently no definite treatment method. Even strong youkai could be at risk from her poison, and it may cause after effects too. However, since she's in the early childhood of not having lived around the range of several hundred years, she is not able to skilfully control her own power, and does not know how to go easy. Even when the opponent is a human, she puts forth all of her power. Because some of her attacks create clouds of poison in the player's side of the field which slow the player's movements and make dodging difficult, she can be a very troublesome opponent for those that don't take care while near poison. Though supposedly not especially powerful or experienced among youkai, the right poison can affect even very strong people or large numbers of people at once.

Incidentally, since she is not a living thing, the poison has no effect on her at all. Since all poison are raw materials for drugs, she would have good compatibility with the drug maker Eirin Yagokoro. The ingredients of seeds that can be taken from plants can cause animals to go insane. She learned that from experience, and she established a way to freely manipulate humans with poison.


Since a few hundred years has still not passed from the time she became youkai, she is a novice youkai. Dolls are usually manipulated by humans. Because of this, she wishes for doll emancipation, but there aren't many dolls who agree with her since dolls can't move to begin with. She was a large doll used in ventriloquism. Although she is labeled as a youkai, Medicine's true nature may be that of a tsukumogami, as described in the Perfect Memento in Strict Sense article about the Eight Million Gods.

Character Design

Illustration of Medicine in Perfect Memento in Strict Sense


She may have been inspired by Agatha Christie, whose favourite flower was none other than the lily-of-the-valley. This is backed up by ZUN's obvious love for Agatha Christie's stories as seen in other characters like Alice Margatroid, Letty Whiterock, and above all Flandre Scarlet. Also, she may have been inspired by Nathaniel Hawthorne's short story, Rappaccini's Daughter, where the title character, Dr. Rappaccini, keeps his daughter, Beatrice, confined in a garden of poisonous flowers, until she became poisonous herself.


Her full name is Medicine Melancholy (メディスン・メランコリー), which may have derived from A Medicine For Melancholy by Ray Bradbury. Also, "medicine" can mean a "drug", and a drug can be "poison" – thus, a natural medicine can be poisonous if it were corrupted for harming purposes. "Melancholy" means to have great sadness or depression, and in archaic terms it means "black bile", or "Melancholia".


Medicine has silver-blue coloured eyes and blonde curly hair. She wears a dark red-purple shirt with red seams, a red skirt with red-purple seams, shoes in the same color and a pink bow at her back. She has a red ribbon in her hair.

She is accompanied by a tiny doll that is similar to her appearance.



Phantasmagoria of Flower View
Medicine's back sprite in PoFV
Medicine's sprite in PoFV

Medicine attacks the player with lily-of-the-valley's poison for no apparent reason other than because they happened to be in her field. Eventually they all get overwhelmed by the poison and leave after the fight. She eventually leaves the field and encounters Eiki Shiki, Yamaxanadu, where she decides she will go against the humans and the status of dolls rise. Though, Eiki states that she is selfish and should understand the pain of others as well. So she gets judged by Eiki at that moment.


Shoot the Bullet
Medicine in HM

In Shoot the Bullet, Aya Shameimaru encountered Medicine on stage 4 and took photos of her danmaku.

Hopeless Masquerade

Medicine made a background cameo appearance in Hopeless Masquerade on the Hall of Dreams' Great Mausoleum stage. She is seen sitting high on the mausoleum whilst cheering something.



She despises all humans that she encounters. Though, she doesn't actually know how to deal with humans. In Perfect Memento in Strict Sense, her human friendship level is listed as "poor" while her danger level is listed as "high".[2]

Eirin Yagokoro

Eirin Yagokoro goes to the Hill of the Nameless to meet Medicine after learning of her from Reisen. Eirin takes an interest in her poisons.

Minor Relationships

Alice Margatroid

Medicine was seen chatting with Alice Margatroid on chapter 9 of Silent Sinner in Blue. In a Touhou Station video, ZUN lists Medicine as a Touhou character whose relationship with Alice is consistently close, confirming that they are at least aware of each other in a positive light.[3]






Name Translated Comments Games Usage
Total: 2
「ポイズンビー」 "Poison Bee" PoFV Charge attack
「スウィートポイズン」 "Sweet Poison" PoFV EX attack

Spell Cards

Spell Cards
Name Translated Comments Games Stage
Total: 5
毒符「神経の毒」 Poison Sign "Nerve Poison" PoFV Use
毒符「憂鬱の毒」 Poison Sign "A Poison for Melancholy" PoFV Use
霧符「ガシングガーデン」 Fog Sign "Gassing Garden" StB St. 4
毒符「ポイズンブレス」 Poison Sign "Poison Breath" StB
St. 4
譫妄「イントゥデリリウム」 Confusion "Into Delirium" StB
St. 4

Additional Information

  • In Phantasmagoria of Flower View, Medicine and Sakuya are the only characters that learn from Eiki's lecture.


Official Profiles

Phantasmagoria of Flower View - キャラ設定.txt
Medicine Melancholy POFV ○小さなスイートポイズン

  Medicine Melancholy







Little Sweet Poison

Medicine Melancholy

Species: Doll
Ability: Manipulating poison

A doll thrown away into a lily-of-the-valley field; over the long years she became a youkai.
Since a few hundred years has still not passed from the time she became youkai, she is a novice youkai.
She possesses ability to manipulate poison

Certain kinds of ingredients, taken from a plant, can drive animals mad. She learned that through experience, and established a method of manipulating humans as she pleases.

In addition, as she is not a living being, poison is harmless against her.

Dolls are usually manipulated by humans. Because of this, she wishes for doll emancipation, but there aren't many dolls who agree with her. To begin with, other dolls don't move on their own...

The suzuran, which weren't expected to bloom, have begun blooming all at once this year. In addition to that, even autumn flowers which weren't supposed to bloom are blooming too. She learned that there are many powers she has never seen in Gensokyo.

Official Sources

Official sources


  1. Phantasmagoria of Flower View (VS Mode): - "Another one without a lifespan. That means another one who has not yet been born, does it?" - Komachi (vs. Medicine)
  2. Perfect Memento in Strict Sense: Medicine Melancholy
  3. From 28 August 2022's Touhou Station, ZUN: "Ahh, [Alice is] a character with few friends. People whose relations with her are close seem few... Such as, Medicine."