Medicine Melancholy

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Medicine Melancholy
me̞disɯ̃ᵝm me̞ɾ̠ã̠ŋko̞ɾiː (♫)
Medicin Melancory
Medicine Melancholy
Medicine Melancholy in Phantasmagoria of Flower View
Little Sweet Poison
More Character Titles

Doll gone youkai


Manipulation of poison




Nameless Hill

Music Themes
Official Games
Print Works

Medicine Melancholy (メディスン・メランコリー Medisun Merankorī) is a young doll youkai that lives on Nameless Hill surrounded by poisonous lily-of-the-valley flowers.

General Information[edit]

Medicine first appeared in Phantasmagoria of Flower View as a possible opponent. She was then later shown as a target on Stage 4 of Shoot the Bullet and in the background of Hopeless Masquerade. She is a doll who became youkai after being left in the lily-of-the-valley field on the Nameless Hill.

Because some of her attacks create clouds of poison in the player's side of the field which slow the player's movements and make dodging difficult she can be a very troublesome opponent for those that don't take care while near poison. Though supposedly not especially powerful or experienced among youkai, the fact that the right poison can affect even very strong people or large numbers of people at once makes her someone best avoided.


Since a few hundred years has still not passed from the time she became youkai, she is a novice youkai. Dolls are usually manipulated by humans. Because of this, she wishes for doll emancipation, but there aren't many dolls who agree with her since dolls can't move to begin with. She was a large doll used in ventriloquism. Even after becoming a youkai, her body is still that of a doll and her experience and knowledge is overwhelmingly shallow. Although she is labeled as a youkai, Medicine's true nature may be that of a tsukumogami, as described in the Perfect Memento in Strict Sense article about the Eight Million Gods.


Manipulating poison

Medicine is able to manipulate poison, where she can uses the poison on everything; food, attacking and even herself could be covered with poison. It seems to be not merely the poison of lily-of-the-valley, but of all kinds. For example, the poison of wasps, snakes, spiders, alcohol, nicotine, etc. It has the effect such that even touching her will cause inflammation; there's currectly no definite treatment method. Even strong youkai could be at risk from her poison, and it may cause after effects too. However, since she's in the early childhood of not having lived around the range of several hundred years, she is not able to skilfully control her own power, and does not know how to go easy. Even when the opponent is human, she puts forth all her power.

Incidentally, since she is not a living thing, the poison has no effect on her at all. Since all poison are raw materials for drugs, she would have good compatibility with the drug maker Eirin Yagokoro. The ingredients of seeds that can be taken from plants can cause animals to go insane. She learned that from experience, and she established a way to freely manipulate humans with poison.

Background Information[edit]

Illustration of Medicine in Perfect Memento in Strict Sense


She may have been inspired by Agatha Christie, whose favourite flower was non other than the lily-of-the-valley. This is backed up by ZUN's obvious love for Agatha Christie's stories as seen in other characters like Alice Margatroid, Letty Whiterock, and above all Flandre Scarlet. Also, she may have been inspired by Nathaniel Hawthorne's short story, Rappaccini's Daughter, where the title character, Dr. Rappaccini, keeps his daughter, Beatrice, confined in a garden of poisonous flowers, until she became poisonous herself.


Her full name is Medicine Melancholy (メディスン・メランコリー), which may have derived from A Medicine For Melancholy by Ray Bradbury. Also, "medicine" can mean a "drug", and a drug can be "poison" – thus, a natural medicine can be poisonous if it were corrupted for harming purposes. "Melancholy" means to have great sadness or depression, and in archaic terms it means "black bile", or "Melancholia.


Medicine has silver-blue coloured eyes and blonde curly hair. She wears a dark red-purple shirt with red seams, a red skirt with red-purple seams, shoes in the same color and a pink bow at her back. She has a red ribbon in her hair.

She is accompanied by a tiny doll that is similar to her appearance.



Phantasmagoria of Flower View
Medicine's back sprite in PoFV
Medicine's sprite in PoFV

Medicine attacks the player with lily-of-the-valley's poison for no apparent reason other than because they happened to be in her field. Eventually they all get overwhelmed by the poison and leave after the fight. She eventually leaves the field and encounters Eiki Shiki, Yamaxanadu, where she decides she will go against the humans and the status of dolls rise. Though, Eiki states that she is selfish and should understand the pain of others as well. So she gets judged by Eiki at that moment.


Shoot the Bullet
Medicine in HM

In Shoot the Bullet, Aya Shameimaru encountered Medicine on stage 4 and took photos of her danmaku.

Hopeless Masquerade

Medicine made a background cameo appearance in Hopeless Masquerade on the Hall of Dreams' Great Mausoleum stage. She is seen sitting high on the mausoleum whilst cheering something.



She despises all humans that she encounters. Though, she doesn't actually know how to deal with humans. In Perfect Memento in Strict Sense, her human friendship level is listed as "poor" while her danger level is listed as "high".[2]

Minor Relationships[edit]

Alice Margatroid

Medicine was seen chatting with Alice Margatroid on chapter 9 of Silent Sinner in Blue, although anything else other than this is unknown.





Spell Cards[edit]

Additional Information[edit]


Official Profiles[edit]

Official Sources[edit]